PEM Inc. grew out of my graduate work at Harvard University, Dept. of Earth and Planetary Sciences, and my time at Biosphere 2, in Tucson, AZ. The need for a single instrument platform that simultaneously measures with high precision and high frequency (1 to 10 Hz) the 12CO2, 13CO2 and 14CO2 composition of a gas has been and still is a goal for PEM. While serving as Director of Science and Research at Biosphere 2 the reflection of Earth processes, while not the same in Biosphere 2 as for the Earth, left an imprint on my thinking. My view is that a biosphere acts across scale from square centimeters to square kilometers. The matrix of physical locations transact the flow of gas and moisture on time scales of micro-seconds to decades between the biosphere and the atmosphere. The imprint of human activity can profoundly alter a biospheric system. The goal of PEM is to understand how to manage the Earth as a system that both preserves the planet and provides a sustained biosphere for future generations.